Journal of Psychiatric Insight Review
Open Access • Peer Reviewed • Quarterly Publication
Ketamine-Assisted Psychotherapy for Addiction: Mechanisms, Evidence, and Clinical Implications
Abstract
Substance use disorders (SUDs) are notoriously difficult to treat due to complex biopsychosocial underpinnings and high relapse rates. Recent evidence positions ketamine-assisted psychotherapy (KAP) as a promising intervention for treatment-resistant addiction. This review explores ketamine’s neurobiological mechanisms, its synergistic effect with psychotherapy, and clinical data supporting its efficacy in various substance use disorders. Additionally, it addresses safety concerns and outlines practical considerations for integration into clinical practice.
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© 2025 The Author(s). Published by WM Journals.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.