Journal of Advances in Physical Medicine & Rehabilitation

Abstract

Background/Aim: Previous researches have revealed associations between Periodontal Disease and diverse types of cancer, such as oral/head and neck cancer, esophageal cancer, gastric cancer, lung cancer, kidney cancer, prostate cancer, hematological malignancies, etc... The current investigation aimed to examine the possible association between Periodontal Disease and the risk of Astrocytoma (grades I-III) development.

Materials and Methods: The sample of the present study was consisted of 45 individuals suffered from Astrocytoma (grades I-III) and 135 matching healthy individuals, who were recruited from one Dental and three Medical private practices. The participants completed a standardized health questionnaire, and underwent a clinical examination. Periodontal status was assessed using the following clinical indices probing pocket depth (PPD), and clinical attachment loss (CAL). Data analysis was performed using univariate and logistic regression models, with adjustments for potential confounders.

Results: The presence of Neurofibromatosis I (p= 0.000, OR= 6.083), and Li-Fraumeni

syndromes (p=0.002, OR= 4.860) were significantly associated with an increased risk of

developing Astrocytoma (grades I-III) compared to healthy controls. In contrast, CAL

(p=0,054) was marginally statistically significant for the risk of Astrocytoma (grades I-

III) development, whereas deeper periodontal pockets (PPD) (p=0.071, OR=1.749) were

not statistically significant, after adjustment for confounding factors such as gender and

age.

Conclusions: The current research suggested that after adjustment for age and gender, CAL demonstrated a borderline statistically significant association with Astrocytoma (grades I-III) risk whereas PPD did not retain statistical significance.