International Journal of Clinical Drug Practice & Pharmacotherapy

Abstract

Background: The Living Therapeutic Materials (LTMs) represent a notable advancement in the fields of Nano, biomedical, and pharmaceutical research. These materials integrate engineered microorganisms with biocompatible matrices, enabling innovative therapeutic functions, particularly in the realm of sustained drug delivery. This review focuses on the current state of LTMs, highlighting preclinical challenges, safety considerations, and recent advancements in the field. The exploration of LTMs seeks to elucidate their potential applications and the obstacles that must be addressed to fully harness their capabilities in therapeutic contexts.

Methods: This review orchestrates recent literature concerning microbe-based Live Therapeutic Materials (LTMs) through in vitro, ex vivo, and in vivo studies. It evaluates various methodologies and performance metrics, focusing on critical aspects such as biocompatibility, immune activation, cytotoxicity, pharmacokinetics, and therapeutic efficacy. The review aims to assess common practices in the field, including advanced therapy medicinal products and live biotherapeutic products (LBPs), highlighting trends and advancements in the development and application of these innovative therapeutic strategies.

Results: The LTMs are shown to produce significant therapeutic outcomes, including functions such as the controlled release of drugs, tissue repair, and immune modulation. Despite these advancements, there are persistent challenges that need to be addressed, particularly concerning genetic stability, regulatory classification, and numerous other issues that impact their use and development.

Conclusion: LTMs are a complex yet promising framework for the creation of next-generation medicines. Al though these treatments have a lot of potential advantages, there are a lot of obstacles that must be overcome to guarantee their effectiveness and safety in clinical settings.