International Journal of Clinical Drug Practice & Pharmacotherapy

Abstract

Adverse drug reactions (ADRs) are a significant cause of morbidity in patients receiving psychotropic medications. Oculogyric crisis (OGC) is a rare extrapyramidal adverse effect characterized by sustained upward deviation of the eyes due to disruption of dopaminergic neurotransmission in the basal ganglia. Although more commonly associated with first-generation antipsychotics, OGC has also been reported with second-generation agents such as olanzapine. We report the case of a 17-year-old female who developed oculogyric crisis associated with gloss ptosis following prolonged treatment with olanzapine. The adverse drug reaction was identified during pharmacovigilance monitoring at Christian Medical College, Ludhiana. Causality assessment using the Naranjo Adverse Drug Reaction Probability Scale indicated a probable association. The patient showed complete clinical recovery following withdrawal of the offending drug. This case highlights a rare and unusual presentation of olanzapine-induced extrapyramidal symptoms and emphasizes the importance of early recognition and pharmacovigilance reporting.