International Journal of Clinical Drug Practice & Pharmacotherapy

Abstract

Drug-induced parkinsonism is a common extrapyramidal adverse effect associated with dopamine receptor-blocking agents. It clinically mimics Parkinson’s disease and is primarily characterized by bradykinesia and rigidity, while tremor and gait instability are less prominent. Although second-generation antipsychotics are generally considered safer than first-generation agents, they may still produce extrapyramidal symptoms, particularly at higher doses. We report the case of a 35-year-old male who developed pseudo parkinsonism and akathisia following treatment with risperidone for a schizophrenia-like psychotic disorder. Causality assessment using the Naranjo Adverse Drug Reaction Probability Scale and WHO-UMC criteria indicated a probable association with risperidone. The patient showed significant clinical improvement following withdrawal of the offending drug. This case highlights the importance of early recognition of extrapyramidal symptoms and cautious use of antipsychotics, even those considered relatively safer, to prevent potentially reversible adverse drug reactions.