Journal of Clinical Oncology & Advanced Therapy

Abstract

Macrophages are phagocytic cells, digest the cellular debris, foreign substances, and microbes. They are equally important for tissue development and homeostasis. Macrophages are generally of two types, one is M1-type, involved in inflammation, aggravating the pathological events, including cardiovascular diseases, diabetes, and neurological disorders. The other one is M2- type, and known for their anti-inflammatory function. The tumor micro-environment (TME) generally loaded with M2-type, and causes the cancer metastasis. The impact of nutrients on immune system, especially on macrophage plasticity is a point of growing research interest. Recent researchers have found pro- and anti-inflammatory properties of some nutrients/diet patterns, which can be used for low-grade inflammatory status correction. In this regard, the assessment of potential effects of nutrition on macrophage differentiation, proliferation, and functioning in health and disease is highly warranted. In this review, we discuss with current data the effects of nutrition on the macrophage functioning in relation to various disease control.