Journal of Clinical Oncology & Advanced Therapy
Open Access • Peer Reviewed • Quarterly Publication
Advanced Squamous Cell Carcinoma of the Vulva (FIGO IIIb): Clinical Presentation, Imaging and Multidisciplinary Management
Abstract
Background: Squamous cell carcinoma of the vulva is a rare malignancy accounting for less than 5% of gynecological cancers. In locally advanced stages (FIGO III–IVA), the prognosis remains poor, particularly when surgical resection is not feasible.
Case Presentation: We report the case of a 69-year-old woman presenting with a moderately differentiated, keratinizing and infiltrating squamous cell carcinoma of the vulva, classified as FIGO IIIb, with large bilateral necrotic inguinal lymphadenopathy. Pelvic MRI revealed a tissue process measuring 62 × 39 × 20 mm and inguino-perineal lymph nodes reaching 47 × 60 mm. The multidisciplinary team decided on neoadjuvant concurrent chemoradiotherapy (CCRT) with curative intent. The course was unfavorable, with the patient dying during a hospitalization for metabolic complications and tumor-related infection.
Conclusion: This case illustrates the diagnostic and therapeutic challenges of locally advanced vulvar cancer and underlines the importance of early detection and prompt multidisciplinary management.
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© 2026 The Author(s). Published by WM Journals.
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