Journal of Clinical Oncology & Advanced Therapy
Open Access • Peer Reviewed • Quarterly Publication
L-Tryptophan Depletion Bioreactor Integrated in the Inuspheresis System for Therapy of Cancer and Autoimmune Diseases and Dementia
Abstract
A variant of double-membrane filtration, Inuspheresis, uses two different second-membrane filters. One of the second hollow fibers is the IN-30 lipid filter for lipid apheresis, and the other is the TKM58 filter for the therapy of autoimmune, inflammatory, environmental, and other diseases. A new bioreactor that contains immobilized tryptophan side-chain oxidase, which de-grades L-tryptophan, will be integrated into the Inuspheresis system to treat all diseases with foreign tissue buildup. L-tryptophan is an essential amino acid and must be brought to the or-ganism with the food. The human cell cannot build up L-tryptophan. L-tryptophan is one of the most important nutrients for foreign tissue growth, especially for cancer cells. The tryptophan side-chain oxidase can therefore be used as therapy for cancer forms, autoimmune diseases with antibodies, Alzheimer disease with tau proteins, and others.
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© 2026 The Author(s). Published by WM Journals.
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