Journal of Advanced Clinical Neurology Research

Abstract

Laser-based therapy may contribute to maintaining hemodynamic equilibrium in affected individuals. The present study was designed to evaluate the levels of the biomarkers homocysteine and creatinine following the clinical application of intravascular laser irradiation of blood (iLIB). We further investigated whether iLIB could improve hematological parameters and examined medication usage before and after iLIB intervention.

Methods: Patients who consecutively underwent iLIB treatment from January 2013 through December 2022 were included for analysis. A retrospective evaluation was conducted to determine the relationship between laboratory findings and iLIB therapy. Clinical characteristics and blood parameters were compared within three months prior to the initial treatment and three months following the final treatment session. Additionally, we analyzed pre- and post-treatment changes between patients receiving 1–9 sessions (Group 1) and those receiving ≥ 10 sessions (Group 1) of iLIB therapy.

Results: A total of 538 eligible individuals who underwent iLIB treatment were analyzed. Following therapy, both homocysteine and creatinine levels showed significant reductions in each group (all p < 0.001). Further more, statistically significant differences between the groups were observed (p < 0.05) for both homocysteine and creatinine.

Conclusions: iLIB therapy appears to be an effective, advantageous, and practical intervention for reducing homocysteine and creatinine levels. The findings of this study suggest that reductions in these biomarkers after iLIB treatment may be indicative of improvements in cardiovascular dysfunction among treated patients.