Journal of Advanced Clinical Neurology Research
Open Access • Peer Reviewed • Bi-Monthly Publication
Transient Aphasia Induced by Fentanyl: A Potential Neurological Adverse Effect
Abstract
Fentanyl, a potent synthetic mu-opioid receptor agonist, is widely used for pain management. Due to its high lipophilicity and low molecular weight, fentanyl can rapidly cross the blood-brain barrier, facilitating its swift entry into the central nervous system (CNS). While many of its adverse drug reactions (ADRs) are well-documented, neurological effects such as aphasia remain exceedingly rare.
We report the case of a 55-year-old female who developed aphasia after receiving fentanyl for postoperative pain. This case was taken from the surgery department as part of the Pharmacovigilance elective under the Department of Pharmacology.
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© 2025 The Author(s). Published by WM Journals.
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