Abstract

Fentanyl, a potent synthetic mu-opioid receptor agonist, is widely used for pain management. Due to its high lipophilicity and low molecular weight, fentanyl can rapidly cross the blood-brain barrier, facilitating its swift entry into the central nervous system (CNS). While many of its adverse drug reactions (ADRs) are well-docu mented, neurological effects such as aphasia remain exceedingly rare. We report the case of a 55-year-old female who developed aphasia after receiving fentanyl for postoperative pain. This case was taken from the surgery department as part of the Pharmacovigilance elective under the Department of Pharmacology.

DOI: doi.org/10.63721/25JACNR01101

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