Abstract

Trans-resveratrol chemically known as 3,5,4'-trihydroxy-trans-stilbenes, is a plant-derived polyphenol with pleiotropic biological activities including antioxidant, anti-inflammatory, cardioprotective, vasodilating and putative anticancer effects. The aim of the present study is to investigate the pharmacokinetics, preclinical and clinical evidence about the impact of trans-resveratrol in pregnancy, its role in cancer prevention and ther apy, and its applications in wome's health. All in vivo or in vitro studies reporting the effects of resveratrol interventions on women's fertility were included. We discuss mechanisms of action, major human trials, safety concerns particularly during pregnancy and provide practical recommendations and research priorities. The current literature, suggests that resveratrol may play an important role in female infertility. Specifically, it may impact the reproductive outcomes, owing to its potential therapeutic effects improving ovarian function. While resveratrol shows promising biological activity and target engagement in multiple tissues, human trials show modest benefits, variable bioavailability, and notable safety signals in some pregnancy models. High-quality randomized trials are needed to define efficacy, optimal dosing, formulation, and safety, especially in pregnant populations.

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